The PS Vita struggles with booting PlayStation Mobile games after an update to firmware 2.00 – but it’s not something that’s difficult to fix.
Essentially when you’ve updated the firmware, the next time you run a PS Mobile game it’ll force another update, this time to the PSM Runtime software, the library that actually boots the PSM games from the Vita’s home screen.
That’s only about 8 MB, and is pretty quick to install.
However, trying a game after that, like Alien Breed, and the Vita just throws up a nasty error (CO-14533-6) and exits the game. We’re not sure if that’s with every PSM game, but it’s possible.
The fix is simple: just reboot your PS Vita once both the firmware update and the PSM Runtime update are done and installed, and the games should load just fine.