Full disclosure: I have no idea what is going on in this trailer, despite watching it three times. As far as I can tell a masked man – presumably evil – creates a giant masked demon lion, so it can have a fight with an unimpressed Norman Reedus. The trailer does confirm Troy Baker’s casting in Death Stranding where he is this masked man.
Hopefully the trailer makes more sense to you.
Death Stranding will be released on an as yet undisclosed date for PlayStation 4.